Advice for Developing Biotherapeutic Antibodies Using ADA and PK Assays
Biotherapeutic antibodies are powerful beause of their tremendous target specificity and their ability to target diverse molecules. Selecting the best candidates for further development requires understanding interactions within the human body – both how a therapeutic is absorbed, distributed, metabolized, and eliminated and whether an antibody will elicit a hypersensitive immune response or interfere with the therapeutic's interaction with its target.
Read this article to learn:
- The 10 measurements used to analyze therapeutic pharmacokinetics
- About identifying potential immune responses that may interfere with a biotherapeutic's effectiveness
- Bio-Rad's custom, fully human anti-idiotypic antibodies
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