at every purification step.

Try our EconoFit Prepacked Columns.​

EconoFit Product

Bio-Rad offers a wide assortment of resins in prepacked columns to support rapid method development and preparative scale purification workflows. EconoFit low-pressure prepacked columns deliver run-to-run uniformity for a range of chromatography applications and easily connect with Bio-Rad NGC Systems or any chromatography system.

Discover our range of EconoFit Prepacked Columns and request a sample below

Affinity chromatography separates proteins based on the attraction of a protein moiety to a ligand bound to the chromatography resin. This technique is performed by either utilizing attraction of native protein moieties to a chromatography resin or engineering a tag into the protein to interact with a specific type of resin. Affinity chromatography is typically the first step in a purification protocol, allowing high enrichment of a protein of interest.

Nuvia IMAC and Profinity IMAC resins offer efficient capture of histidine‑tagged proteins.​

Nuvia IMAC, Ni‑Charged​

Ultra‑high capacity for histidine‑tagged proteins.​​

Nuvia IMAC, Uncharged​​

Charge with a transition metal of your choice.​​​​

Profinity IMAC, Ni‑Charged​​

For larger and difficult‑to‑purify histidine-tagged proteins.​​​​

Ion exchange (IEX) separation occurs through a charged protein of interest being attracted to an oppositely charged chromatography resin. Separation of proteins is performed by changing the ionic strength or pH of the solution in a manner that differentially changes the binding properties of proteins interacting with the matrix. IEX can be used for protein isolation, intermediate purification, or as a polishing technique.

Macro‑Prep IEX resins combine high resolution and capacity, providing solutions for any purification step.

UNOsphere and Nuvia resins are designed for capture and intermediate steps, and their bead size makes them ideal for use with crude samples.​

Macro‑Prep High Q and High S​​

Strong ion exchange resins that combine good to high resolution and high capacity; ideal for purifying acidic (High Q) / basic (High S) and neutral proteins and peptides.​​​

Macro‑Prep DEAE and CM​​​

Weak anion (DEAE) / cation (CM) exchange resins that offer different selectivity than strong ion exchangers.​​​​​

UNOsphere Q and S​​​

Strong anion (Q) / cation (S) exchange resins that exhibit high capacity and allow capture from crude lysates.​​​​​

Nuvia Q and S

Strong anion (Q) / cation (S) exchange resins that provide ultra‑high capacity.​​​​​​

Nuvia HP‑Q

​High capacity, strong anion exchange resin for the purification of large biomolecules such as IgA and IgM or viruses.​​​​​​​

​Nuvia HR‑S​

High‑resolution, strong cation exchange resin for separating closely related biomolecules.​​​​​​​​

Mixed‑mode or multimodal chromatography is a technique that offers unique separation properties due to the use of multiple separation modalities. Using mixed-mode chromatography as an intermediate purification or polishing step can offer unparalleled selectivity and resolution for a variety of biomolecules.​

Ceramic Hydroxyapatite (CHT™) resin, with the unique capability to remove Protein A, endotoxins, nucleic acids and aggregates, is considered an industry standard for the purification of antibodies and is ideal for the second or third step of an antibody purification workflow.​

Nuvia aPrime 4A and cPrime resins combine hydrophobic interaction​ and ion exchange modalities to achieve effective purification.​

CHT Type I​

Offers unique separation properties and unparalleled selectivity and resolution; purify a variety of biomolecules ranging from antibodies to viruses. Available as 40 or 80 µm sized particles.​

CHT Type II​​​

Same benefits as CHT Type I, but with larger pores making it suitable for larger biomolecules such as IgM or viruses. Available as 40 or 80 µm sized particles.​


Provides exceptional clearance of impurities and aggregates for monoclonal antibody purification. Offers selectivity between CHT Type I and Type II.​​​​​

Nuvia aPrime 4A and cPrime​

Anionic (aPrime 4A) or cationic (cPrime) hydrophobic media that deliver both high purity and yield for difficult‑to‑purify biomolecules.​​​​​​

Hydrophobic interaction chromatography (HIC) separates molecules based on their hydrophobicity. HIC is a useful separation technique for purifying proteins while maintaining biological activity due to the use of conditions and matrices that operate under less denaturing conditions.​

Macro‑Prep HIC resins are designed specifically for intermediate purification steps that remove host‑cell contaminants from partially purified targets.​

Macro Prep Methyl

Weakly hydrophobic, for purifying biomolecules that have strong hydrophobic regions.

Macro Prep t Butyl

Mildly hydrophobic, for purifying compounds that have few or weakly hydrophobic regions.​​​​

Complete this form to request an EconoFit sample.

Thank you for requesting a sample of our EconoFit Prepacked Columns.

You will receive confirmation of your sample request within 2-3 business days. For more information about our chromatography columns and resins, download our selection guide.