Serum Indices


Monitor the Ability of an Instrument to Detect Pre-Analytical Interferences

Hemolysis, Icterus and Lipemia (HIL) are the most commonly tested interferences that affect the integrity of patient samples in the clinical laboratory and can impact patient results.

Common chemistry assays with known sensitivity to HIL interferences:

Hemolysis Icterus Lipemia
Amylase (AMY)
Aspartate Aminotransferase (AST)
Magnesium (MG)
Iron (FE)
Lactate Dehydrogenase (LDH)
Direct Bilirubin (DBI)
Potassium (K)
Amylase (AMY)
Creatinine (SC)
Iron (FE)
γ-Glutamyl Transferase (GGT)
Triglycerides (TG)
Potassium/Sodium (K/Na)
Aspartate Aminotransferase (AST)
Direct Bilirubin (DBI)
Magnesium (MG)
Iron (FE)
Lactate Dehydrogenase (LDH)
Potassium (K)
Sodium (Na)

Including a pre-analytical check of HIL interferences in your QC program can ensure they are being accurately identified by your instrument, adding confidence to patient results and minimizing the risk to patient harm.

Regulators are taking note:

ISO 15189:2012 includes expanded pre-examination procedures, and the IFCC* is recommending standardized “Quality Indicators” in an effort to reduce the volume of pre-analytical errors.1

Learn about the importance of screening for pre-analytical errors to ensure quality results in your laboratory:

What is Liquichek Serum Indices?

Liquichek Serum Indices is a product that is intended for use as part of laboratory interference testing to monitor the ability of the instrument to detect Hemolyzed, Icteris or Lipemic (HIL) samples. Liquichek Serum Indices consists of three independent interferents (Hemolysis, Icterus, and Lipemia) and one non-interfered serum sample.

Resemble Patient Samples

Reduce Human Errors

Identify Potential Drift and Failure

Resemble patient samples with human sourced material
Liquid, human sourced materials containing HIL interferent adds confidence to instrument performance.

Reduce human errors by eliminating manual inspections
Monitoring automated HIL detection with Liquichek Serum Indices may help eliminate hands-on time and ensure reliable results, eliminating the need for subjective visual assessment.

Identify potential drift and failure by comparing instrument responses among peer groups
Unity interlaboratory program can offer early awareness of drift and trends to help identify potential dift and failure.

Product Details:


  • Prepared from human source material
  • 6 month shelf life at -20°C to -70°C
  • 5 day open-vial stability at 2-8°C
  • 7 day closed-vial stability at 2-8°C
  • 28 day frozen aliquot at -20°C to -70°C

Icterus, Lipemia and Non-interfered

  • Prepared from human source material
  • 2 year shelf life at -20°C to -70°C
  • 14 day open-vial stability at 2-8°C
  • 14 day closed-vial stability at 2-8°C
  • 28 day frozen aliquot at -20°C to -70°C

Improve laboratory analytical performance by including Liquichek Serum Indices as part of your individualized quality control plan for detecting HIL interferences.

Frequently Asked Questions

I manually inspect for interferences in my patient sample. Why should I use Liquichek Serum Indices?

Most chemistry analyzers now have onboard automated HIL detection to determine if the integrity of a patient sample has been compromised by HIL interferences. Liquichek Serum Indices can be run automatically to help assure that the instrument is performing as expected when detecting HIL interferences.

What if I don't have time to track performance for each of my instruments for HIL detection?

You can quickly and easily enter your results and track instrument performance in Bio-Rad's Unity interlaboratory program. In addition to monitoring the performance of your laboratory, you can also compare to other reporting labs using the same instrument.

Pre-analytical testing of the instrument to detect HIL interferences is not mandated by regulations, so what is the value in performing these tests?

ISO15189:2012 supports the identification and control of non-conformities within the pre-analytical testing process. In addition, thought leaders from the European Federation of Clinical Chemistry, Laboratory Medicine (EFLM) Working Group, for Preanalytical Phase, recently published their expert opinion about management of internal quality control assessment for HIL indices. Read the article in the Journal of Clinical Biochemistry for details.

You may wish to include a product such as Liquichek Serum Indices as part of your individualized Quality Control Program (IQC) to perform pre-analytical checks to monitor instrument performance to detect HIL samples.

What instruments are compatible with Liquichek Serum Indices?

Liquichek Serum Indices works on most major chemistry instruments such as Abbott, Beckman, Roche, Ortho and Siemens.

About Us

Bio-Rad offers a comprehensive portfolio of products to cover all phases of clinical chemistry testing and data management.

  • Liquichek Serum Indices – pre-analytical detection of hemolysis, icterus and lipemia (HIL) interferences to monitor instrument's ability to respond to these interferences.
  • Quality Controls – a wide range of QC products to help your lab run smoothly and maintain your quality system.
  • Unity Interlaboratory Program - data management solution to help manage QC data and powerful peer group comparisons for greater confidence in patient test results.

You can count on our consistent product quality to help assure reliability.

1. Green, S. F. The cost of poor blood specimen quality and errors in preanlytical processes. Clin BioChem. 2013;46:1175-9

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