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Haemolysis, icterus and lipemia (HIL) are the most commonly tested interferences that affect the integrity of patient samples in the clinical laboratory. Depending on the type and the degree of interferences, it may impact patient results.

Common chemistry assays with known sensitivity to HIL interferences:

Amylase (AMY)Amylase (AMY)Aspartate Aminotransferase (AST)
Aspartate Aminotransferase (AST)Creatinine (SC)Direct Bilirubin (DBI)
Magnesium (MG)DigoxinMagnesium (MG)
Iron (FE)Iron (FE)Iron (FE)
Lactate Dehydrogenase (LDH)γ-Glutamyl Transferase (GGT)Lactate Dehydrogenase (LDH)
Direct Bilirubin (DBI)Triglycerides (TG)Potassium (K)
Potassium (K)Potassium/Sodium (K/Na)Sodium (Na)

Although most major laboratory systems include automated HIL detection features to measure common interferences, including pre-analytical checks in your QC programme can ensure that they are being accurately identified.

Building your QC strategy for HIL interference checks

Join us and Dr. von Meyer, the EFLM’s pre-analytical working group chairman:

  • The importance of pre-analytical checks in ensuring quality results in your laboratory
  • Simple strategies to improve your quality assurance for pre-analytical work in your laboratory
  • Practical ways to manage your instruments if your QC fails

Register for the webinar

Liquichek Serum Indices

Liquichek Serum Indices is a quality indicator intended for use as part of laboratory interference testing to monitor an instrument’s ability to detect haemolysed, icteris and or lipemic samples.

  • Liquid, human source material based matrix
  • 2 year shelf life at -20°C to -70°C
  • 30 day unopened stability at 2-8°C
  • 14 day open-vial stability at 2-8°C

Resemble patient samples with human sourced material

Analysing realist concentrations of HIL interferences using human-sourced materials can increase confidence in your instruments’ performance.

Compare instrument responses among peer groups with Unity Interlaboratory Programme
An interlaboratory program can offer early awareness of shifts and trends to help avoid costly test repeats and unnecessary troubleshooting.

Read the poster

presented at EFLM for HIL pre-analytical monitoring

View the poster

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Frequently Asked Questions

I manually inspect for interferences in my patient sample. Why should I use Liquichek Serum Indices?
Most chemistry analysers now have on-board automated HIL detection to determine if the integrity of a patient sample has been compromised by HIL interferences. Liquichek Serum Indices can be run automatically to help assure that the instrument is performing as expected when detecting HIL interferences.

What if I don't have time to track performance for each of my instruments for HIL detection?
You can quickly and easily enter your results and track instrument performance in Bio-Rad's Unity Interlaboratory program. In addition to monitoring the performance of your laboratory, you can also compare to other reporting labs using the same instrument.

Pre-analytical testing of the instrument to detect HIL interferences is not mandated by regulations, so I don’t see value in doing it?
ISO15189:2012 supports the identification and control of non-conformities within the pre-analytical testing process. You may wish to include a product such as Liquichek Serum Indices as part of your Quality Control programme to monitor your instruments’ ability to detect HIL samples.

I have several instruments in my lab – will your product work on all of them?
Liquichek Serum Indices works on most major chemistry instruments such as Abbott, Beckman, Ortho, Roche and Siemens.

Learn More

Serum Indices Video ▸  

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