Microsatellite instability (MSI) status is routinely assessed in patients with colorectal and endometrial cancers as it contributes to Lynch syndrome initial screening, tumour prognosis, and selecting patients for immunotherapy. Currently, standard reference methods recommended for MSI/dMMR (deficient MisMatch Repair) testing consist of immunohistochemistry and pentaplex PCR-based assays, however, novel molecular-based techniques are emerging. During this webinar, Dr Alexandre Harlé will present the results of his performance evaluation of the Bio-Rad ddPCR assay.
Dr. Alexandre Harlé, PharmD, PhD,
Assistant Professor at Institut de Cancérologie de Lorraine and Université de Lorraine, Faculté de Pharmacie, CNRS UMR7039 CRAN, Nancy, France.
Dr. Alexandre Harlé (PharmD, PhD) is the head of the translational research and liquid biopsy group at the Lorraine Cancer Institute in Nancy France. His work focuses on how to translate liquid biopsy in clinical practice and also deciphering tumour heterogeneity, clonal evolution and minimal residual disease using cfDNA as a surrogate to tissue biopsy.