BioPlex 2200 Syphilis Total & RPR Assay

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The BioPlex 2200 Syphilis Total & RPR assay offers an automated one-step testing method

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Qualitative detection and/or titer determination of non-treponemal reagin antibodies in human serum or plasma

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Qualitative detection of Total (IgG/IgM) antibodies to Treponema pallidum

One test. Two results.

The BioPlex 2200 Syphilis Total & RPR assay eliminates the need to maintain multiple methods for syphilis testing. Our automated dual treponemal/non-treponemal immunoassay offers laboratories both syphilis total and RPR results from a single test.

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Simultaneous detection and differentiation of treponemal and non-treponemal antibodies

The BioPlex 2200 Syphilis Total & RPR assay is the only dual treponemal/non-treponemal immunoassay test that offers laboratories an automated one-step testing solution for syphilis screening. It's a simple approach. Just load your samples and walk away.

A paradigm shift in syphilis diagnosis


Simplicity: Streamline your workflow

Challenges involving traditional test methods can include manual labor, longer wait times for results, and the need to conduct two different test methods/assays. Simplifying your workflow using the BioPlex 2200 System one-step method can help alleviate the chaos.

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BioPlex 2200 Syphilis Total & RPR test
Traditional or reverse algorithm method

Features of the BioPlex Syphilis & RPR test

  • Dual treponemal/non-treponemal assay
  • Automated RPR (1:1)
  • Onboard titer dilutions (1:4, 1:8, 1:16, 1:32, 1:64)*
  • Up to 200 results per hour
  • Excellent precision
  • Ready to use reagents
  • 30 day calibration curve stability
  • * titers <1:4 and >1:64 are also available through manual dilution procedure

Benefits of the BioPlex Syphilis & RPR test

  • Accurate, consistent and objective RPR result reporting
  • Full traceability
  • Better patient management

Challenges of traditional methods

  • Longer turnaround time for final result
  • Need to maintain at least two different methods/assays
  • Manual RPR testing and result reporting

Quality: Be confident in your results

The performance of our BioPlex 2200 Syphilis Total & RPR assay provides improved sensitivity and specificity including differentiation of current and/or past infection compared to traditional methods. It also offers excellent accuracy/precision and objective RPR result reporting.

  • Excellent negative agreement with commercially available methods for both Syphilis Total (98.9%) and RPR (99.5%)
  • Excellent positive agreement with commercially available methods for medically diagnosed samples for Syphilis Total (99.1%) and RPR (100%)
  • Excellent total precision for Syphilis Total (≤11.2%) and RPR (≤13.4%)
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Efficiency: Maximize laboratory productivity

Implement efficiency in your lab with reduced hands-on time and labor savings enabling higher total throughput — up to 200 results per hour. Additionally, with a dual treponemal/non-treponemal assay, you can streamline your syphilis testing algorithm and free yourself from conducting multiple methodologies to obtain a test result.

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BioPlex 2200 Syphilis Total and RPR assay principle

This test panel is a dual treponemal/non-treponemal assay. The bead reagent consists of two distinct populations of dyed microparticle beads in addition to two internal quality beads.

Internal QC Beads
Beads are combined into a single bead reagent for multiplex analysis.

  Internal Standard Bead (ISB)
  Serum Verification Bead (SVB)

Intended Use
The BioPlex 2200 Syphilis Total & RPR kit is a multiplex flow immunoassay intended for the qualitative detection of total (IgG/IgM) antibodies to Treponema pallidum and the qualitative detection and/or titer determination of non-treponemal reagin antibodies in human serum or plasma. The Syphilis Total or RPR assays may be used to supplement a previously determined reactive treponema or non-treponema test. The test system should be used in conjunction with other laboratory tests and clinical findings to aid in the diagnosis of syphilis infection.

The BioPlex 2200 Syphilis Total & RPR kit is not intended for use in screening blood or plasma donors.

The BioPlex 2200 Syphilis Total & RPR kit is intended for use with the Bio‑Rad BioPlex 2200 System.

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Product information

Learn more about the BioPlex 2200 Syphilis Total & RPR assay. The only automated dual treponemal/non-treponemal immunoassay test that offers laboratories an automated one-step testing solution for syphilis screening.

Case studies

Review the following case study on the BioPlex 2200 Syphilis Total and RPR assay. Get multiple perspectives from the the scientists who wrote them.

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