Streamline your routine HbA1c testing using the D-100 system. It combines the security of HPLC technology with a unique ‘one-touch’ operation to simplify the workflow – all without sacrificing the accurate and precise results you depend upon.
The table below shows the number of manual steps required to process the daily HbA1c workload:
Activity | Immunoassay | Cap Electro | Other HPLC | D-100 |
Daily Maintenance | • | • | • | |
Instrument start-up | • | • | • | |
Reagent preparation | • | • | ||
QC preparation | • | • | • | • |
QC running | • | • | • | • |
QC data entry | • | • | • | Automatic |
Sample mixing | • | |||
Sample preparation | • | • | • | |
Sample running | • | • | • | • |
TOTAL MANUAL STEPS | 9 | 8 | 7 | 3 |
Compiled from assay instructions, the graph below summarises the total number of interactions required to process 10,000 HbA1c tests:
D-100
VII Turbo
HPLC 1
HPLC 2
Cap Elect
HPLC 3
Based on actual observations in customer laboratories, the spaghetti diagrams below illustrate the operator movements required to prepare an HbA1c run:
D-100 SystemTypical movement of operators to prepare 6 D-100 systems • NO daily maintenance • NO start-up activitie • Automatic QC (with Unity) | ![]() |
Immunoassay SystemTypical movement of operators to prepare 2 immunoassay systems • Daily maintenance • Start-up activities • Manual QC transcription | ![]() |
The following data shows the total time taken for the first HbA1c result of the day to be produced - with daily maintenance, instrument start-up and running QC included.
Based on actual laboratory observations, the diagram below illustrates the total processing time required for 300 samples:
The complexity of sample preparation varies by type of technology, but typically includes the following steps:
D-100 System
HPLC
Capillary Electro
Immunoassay 1
Immunoassay 2
The D-100 system requires very little operator maintenance compared to a capillary electrophoresis system:
D-100 System![]() Clean the System - Automatic, every 30,000 tests | Capillary Electrophoresis![]() Clean the Capillaries - Manual, every 500 samples Clean the Probe - Manual, every week Prepare Wash Solution - Manual, every 600 samples Replace DI Water - Manual, every day |
“In general we can say that we have never worked with an instrument which is as easy to use as the D-100. Bio-Rad has really listened to the wishes of users with regards to ease of use of the instrument. The analytical performance of the D-100 is excellent.”
Klinisch Chemisch Laboratorium, Isala Zwolle, Netherlands
“The Bio-Rad D-100 system is a fully automated, user-friendly, high throughput HPLC system giving accurate and reproducible results. The system showed a reduced hands-on time, simple calibration process, very good workflow efficiency thanks to the intuitive interface, and a high speed HbA1c assay in 45 seconds. D-100 therefore displays the appropriate characteristics to be used as a routine method in clinical laboratories.”
Centro per la Riferibilità Metrologica in Medicina di Laboratorio, Università degli Studi, Milano
“With an 80‑test hourly throughput and a 10,000 sample analytical column, the D-100 system meets the needs of high volume laboratories. The D-100 also maximises workflow efficiency. We found that it provides a consistent and thorough review of every result. With the built-in result review criteria and the bi‑directional LIS interface, >90% of our patient samples are run and verified with no technician intervention.”
Maricopa Integrated Health System, Phoenix, AZ
If you would like your HbA1c testing to be more streamlined and
efficient, book a LabInsight Workflow Assessment today and
discover how we can help optimise your routine HbA1c workload.