Generating custom tool antibodies against various antigen types can be technically challenging, especially when working across varied formats like monoclonal antibodies, bispecifics, CAR constructs, antibody-drug conjugates (ADCs), antibody-oligonucleotide conjugates (AOCs), and engineered complex constructs. Bio-Rad’s HuCAL® antibody generation services via a phage display library offer a powerful solution, enabling the selection of highly specific binders for diverse and complex targets.
In this webinar exclusively for Takeda, we describe the fundamentals of antibody phage display and its application in generating custom tool antibodies. We will explore the development of different types of anti-idiotype antibodies tailored to various formats, including mAbs, bispecifics, and scFvs used in CAR-T therapies. Successful generation of antibodies against MMAE payloads and siRNA will be highlighted to showcase solutions to difficult targets. We’ll also introduce TrailBlazer™, our modular antibody assembly system that streamlines format switching and screening to accelerate bioassays.
You will learn:
- How antibody phage display enables precise and efficient tool antibody generation
- Design strategies for anti-ID antibodies across multiple formats (mAb, bispecific, CAR)
- Insights into generating antibodies against siRNA and ADC payload MMAE
- How SpyTag technology enables TrailBlazer platform for rapid format switching
Paul Royle, PhD,
Market Development Manager, Bio-Rad
Paul Royle is the Market Development Manager for Bio-Rad’s Custom Antibody Service and has been with Bio-Rad’s Antibody Division for 12 years. Prior to this, he worked in an immunology diagnostics company for almost 7 years. Paul holds a degree and PhD from the University of Nottingham, UK, and has post-doctoral research experience from the University of Warwick, UK.